Class

Drug

Neuroleptic Malignant Syndrome

Parkinsonism

Acute or Tardive Dyskinesia

Akathesia

Tardive Dyskinesia

Tremor

Chorea

Myoclonus

Tic

Antidepressants

Tricyclics

x

x

xx

xx

50%

Rare

9-40%

Monamine Oxidase Inhibitors

x

x

x

15%

xx

SSRIs

x

xx

xx

x

8%

x

xx

x

Trazodone

x

x

x

Buproprion

x

x

x

x

x

Effexor

4%

2%

x

5%

3%

Celexa

x

x

x

x

Serzone

x

x

x

x

xx

xx

Remeron

x

x

x

x

7%

x

x

Anxiolytics

Buspirone

x

x

x

x

x

x

x

x

Diazepam

x

x

x

x

Withdrawal

x

Clonazepam

x

x

x

x

Withdrawal

x

Lithium

x

x

x

50 - 65%

x

x

Stimulants

Amphetamines

x

x

x

x

xx

x

x

xxx

Cocaine

x

x

x

x

xx

x

x

xxx

Methylphenidate

x

x

x

x

xx

x

x

xxx

Anticonvulsants

Valproic Acid

xx

xx

x

x

xx

x

xxx

Carbamazepine

x

x

x

x

x

Topiramate

6%

x

Diphenylhydantoin

x

xx

x

xx

xxxx

xxx

Phenobarb

x

x

x

x

Gabapentin

x

xxx

x

xxx

Lamotrigine

x

x

x

Antipsychoics (Typical)

xxxx

xxxx

xxxx

xxx

xxx

xxx

xxx

xxx

xxx

Antipsychotics (Atypical)

Risperidone

7-13%

3%

3%

x

2%

Olanzepine

12-15%

2-3%

5%

5-10%

4%

2%

Seroquel

4-6%

2%

x

Clozapine

3%

3%

1%

6%

Class

Drug

Neuroleptic Malignant Syndrome

Parkinsonism

Acute or Tardive Dyskinesia

Akathesia

Tardive Dyskinesia

Tremor

Chorea

Myoclonus

Tic

H1 Antihistamines

Chlorphenipramine

x

x

x

x

H2 Antihistamines

Cimetidine

xx

x

x

xx

x

Ranitidine

xx

x

x

xx

x

Anticholinergics

Trihexiphenidyl

x

x

Cogentin

x

x

Cholinergics

Bethanocol

x

x

Pyridostigmine

x

x

Antibiotics

Amphoteracin B

x

Penicillin

xx

Cephalosporins

xx

Septra

x

x

Chloroquine

x

Adenosine Arabinoside

x

Acyclovir

x

Izoniazid

x

Cardiac Drugs

Amiodarone

x

x

xx

x

Digoxin

xx

Anti Neoplastics

Cytosine Arabinoside

x

Vincristine

x

x

Methotrexate

x

5-Fluoruracil

x

x

Doxyrubicin

x

x

Class

Drug

Neuroleptic Malignant Syndrome

Parkinsonism

Acute or Tardive Dyskinesia

Akathesia

Tardive Dyskinesia

Tremor

Chorea

Myoclonus

Tic

Oral Contraceptives

x

xxx

Opiates

Meperidine

x

x

x

x

Morphine

x

xx

xxx

Oxycodone

x

x

x

Methadone

x

x

Fentenyl

x

x

x

x

Calcium Channel Blockers

Verapamil

xx

Diltiazem

xx

xx

Flunarazine

xx

xx

AntiNauseants

Metochlopramide

x

xxx

xx

xx

xxx

xxx

xx

xx

Stemetil

x

xxx

xx

xx

xxx

xxx

xx

xx

Others

Naproxen sodium

x

Ethanol (Toxic or withdrawal)

x

xx

Procaine

x

Etretinate

x

Sumatryptan

x

Methylsergide

x

Cyproheptadine

x

x

x

Theophyline

xxx

Thyroxine

xxx

Hypoglycemics

xxx

Steroids

xxx

x

Nicotinic Acid

xxx

Baclofen

x

Tryptophan

x

Propofol

x